Experiment 1074926
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV BOLUS |
| Organism | Catharanthus roseus (APOCYNACEAE) |
| Citation | OHNUMA,T: GREENSPAN,EM: HOLLAND,JF:. (1980). INITIAL CLINICAL STUDY WITH VINDESINE: TOLERANCE TO WEEKLY IV BOLUS AND 24-HOUR INFUSION.. 64() |
| Amount utilized | |
| Compound isolated | |
| Disease | CLINICAL STUDY INVOLVING 46 PATIENTS WITH INOPERABLE CANCER AND LEUKEMIA IN RELAPSE. DOSING ONCE WEEKLY WELL TOLERATED BY PATIENTS WITH NORMAL LIVER FUNCTION DOSE-LIMITING SIDE EFFECTS WERE LEUKOPENIA AND NEUROTOXICITY.LEUKOPENIA WAS CUMULATIVE BUT EASILY REVERSIBLE BY INTERRUPTION OF WEEKLY DOSE.NEUROTOXICITY WAS INSIDIOUS AND HARDLY REVERSI NO OBJECTIVE RESPONSES |
| Dose amount | 2-5.5 MG |
| Number | 2 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |