Experiment 1075050
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Gossypium hirsutum (MALVACEAE) |
| Citation | NADAKAVUKAREN,MJ: SORENSEN,RH: TONE,JN:. (1979). EFFECT OF GOSSYPOL ON THE ULTRASTRUCTURE OF RAT SPERMATOZOA.. 204() |
| Amount utilized | |
| Compound isolated | |
| Disease | DAILY DOSING FOR 4 WEEKS. GOSSYPOL "ACETATE" WAS USED IN THE STUDIES. SOURCE AND DEGREE OF PURITY UNSTATED. SPERM WERE FOUND IN BOTH CONTROL AND GOSSYPOL-TREATED EPIDIDYMIS SECTIONS(ELECTRON MICROSCOPY). NO GROSS MORPHOLOGICAL DIFFERENCES IN SPERMATOZOA OF BOTH GROUPS. DISORGANIZATION OF THE MITOCHONDRIA SHEATH OF THE SPERM TAILS IN GOSSYPOL-TREATED ANIMALS WAS SEEN IN BOTH LONGITUDINAL AND CROSS SECTIONS OF THE MIDDLE PIECE. SOME MITOCHONDRIA APPEARED EMPTY. CELL MEMBRANE BROKEN AND OFTEN COMPLETELY MISSING FROM LARGE SEGMENTS OF THE MIDDLE PIECE. |
| Dose amount | 40.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |