Experiment 1075926
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Gossypium hirsutum (MALVACEAE) |
| Citation | TANG,XC: ZHU,MK: SHI,QX:. (1980). COMPARATIVE STUDIES ON THE ABSORPTION, DISTRIBUTION AND EXCRETION OF 14C-GOSSYPOL IN FOUR SPECIES OF ANIMALS.. 15(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | C-14 LABELLED GOSSYPOL WAS USED PEAK BLOOD LEVEL WAS 6-9 HRS AFTER ADMINISTRATION.BIOLOGICAL HALF-LIFE WAS 16.5 HRS RADIOACTIVITY WAS FOUND IN ALL TISSUES EXAMINED AFTER 48 HOURS.HIGHEST LEVELS IN G.I.TRACT,WITH LEVELS IN LIVER AND KIDNEY NEXT HIGHEST.TESTES LEVELS HIGHER IN THE RAT THAN IN THE MOUSE MAIN ROUTE OF ELIMINATION WAS VIA THE FECES,ONLY SMALL AMOUNTS IN THE URINE IT IS SUGGESTED THAT DIFFERENCES IN DISTRIBUTION,RATE OF ABSORPTION AND ELIMINATION MAY ACCOUNT FOR SPECIES DIFFERENCE TOWARD THE ACTIVITY OF GOSSYPOL |
| Dose amount | 15.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |