Experiment 1076122
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Maytenus ovata (CELASTRACEAE) |
| Citation | FRANKLIN,R: SAMSON,MK: FRAILE,RJ: ABU-ZHARA,H: O'BRYAN,R: BAKER,LH:. (1980). A PHASE I-II STUDY OF MAYTANSINE UTILIZING A WEEKLY SCHEDULE.. 46() |
| Amount utilized | |
| Compound isolated | |
| Disease | A PHASE I-II STUDY INVOLVING 107 CANCER PATIENTS DOSE-LIMITING TOXIC REACTIONS CONSISTED OF CENTRAL NEUROPATHY AND PERIPHERAL NEUROPATHY.OTHER TOXIC REACTIONS WERE NOT CONSIDERED DOSE-LIMITING(NAUSEA,VOMITING,DIARRHEA). VERY LITTLE MYELOSUPPRESSION. TWO PARTIAL REMISSIONS IN THE PHASE I STUDY,ONE IN THE PHASE II STUDY. RECOMMENDATION TO STUDY FURTHER IN COMBINATION CHEMOTHERAPY DUE TO LOW INCIDENCE OF MYELOSUPPRESSION. |
| Dose amount | 1.0 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |