Experiment 1076318
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IN RATION |
| Organism | Empty organism |
| Citation | FRIEDMAN,L: WEINBERGER,MA: FARBER,TM: MORELAND,FM: PETERS,EL: GILMORE,CE: KHAN,MA:. (1979). TESTICULAR ATROPHY AND IMPAIRED SPERMATOGENESIS IN RATS FED HIGH LEVELS OF THE METHYLXANTHINES CAFFEINE, THEOBROMINE, OR THEOPHYLLINE.. 2() |
| Amount utilized | |
| Compound isolated | |
| Disease | DAILY FEEDING FOR 14-75 WEEKS IN 5-6 WEEK-OLD RATS. 80% (4(5) OF ANIMALS SHOWED TESTICULAR ATROPHY, 60% (3/5) SHOWED OLIGOSPERMATOGENESIS AND 20% (1/5) SHOWED ASPERMATOGENESIS AFTER 14 WEEKS. 100% (8/8) OF ANIMALS SHOWED TESTICULAR ATROPHY, 38% (3/8) SHOWED OLIGOSPERMATOGENESIS AND 62% (5/8) SHOWED ASPERMATOGENESIS AT END OF 75 WEEKS. HISTOPATHOLOGY IS PRESENTED AND DISCUSSED. |
| Dose amount | 0.5 % OF DIET |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | CONC USED |
| Gender | MALE |