Experiment 1076319
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IN RATION |
| Organism | Empty organism |
| Citation | FRIEDMAN,L: WEINBERGER,MA: FARBER,TM: MORELAND,FM: PETERS,EL: GILMORE,CE: KHAN,MA:. (1979). TESTICULAR ATROPHY AND IMPAIRED SPERMATOGENESIS IN RATS FED HIGH LEVELS OF THE METHYLXANTHINES CAFFEINE, THEOBROMINE, OR THEOPHYLLINE.. 2() |
| Amount utilized | |
| Compound isolated | |
| Disease | DAILY FEEDING FOR 19 WEEKS IN 4 WEEK OLD RATS. 100% (11/11) OF ANIMALS SHOWED TESTICULAR ATROPHY, 9% (1/11) SHOWED OLIGOSPERMATOGENESIS AND 91% (10/11) SHOWED ASPERMATOGENESIS AFTER 19 WEEKS. HISTOPATHOLOGY IS PRESENTED AND DISCUSSED. |
| Dose amount | 0.5 % OF DIET |
| Number | 3 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | CONC USED |
| Gender | MALE |