Experiment 1076323

Worktypes

PHARMACOLOGY OF COMPOUND - IN VIVOANTIFERTILITY

Compounds isolated

THEOBROMINE

Alerts

BIOLOGICAL DATA FOR THIS COMPOUND ARE INCOMPLETE. SEE ARTICLE.STATISTICAL DATA IN REPORT INDICATING SIGNIFICANT RESULTS.

Details

PropertyValue
Pharmacology
ANTISPERMATOGENIC EFFECT
Administration routeIN RATION
OrganismEmpty organism
CitationFRIEDMAN,L: WEINBERGER,MA: FARBER,TM: MORELAND,FM: PETERS,EL: GILMORE,CE: KHAN,MA:. (1979). TESTICULAR ATROPHY AND IMPAIRED SPERMATOGENESIS IN RATS FED HIGH LEVELS OF THE METHYLXANTHINES CAFFEINE, THEOBROMINE, OR THEOPHYLLINE.. 2()
Amount utilized
Compound isolated
DiseaseDAILY FEEDING FOR 19 WEEKS IN 4 WEEK OLD RATS. 100% (14/14) OF ANIMALS SHOWED TESTICULAR ATROPHY, 21% (3/14) SHOWED OLIGOSPERMATOGENESIS AND 79% (11/14) SHOWED ASPERMATOGENESIS AFTER 19 WEEKS. HISTOPATHOLOGY IS PRESENTED AND DISCUSSED.
Dose amount0.5 % OF DIET
Number2
Qualitative resultACTIVE
AnimalRAT
Dose expressionCONC USED
GenderMALE