Experiment 1077429
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Empty organism |
| Citation | ZHOU,LF: CHEN,CC: WANG,NK: LEI,HP:. (1980). EXPERIMENTAL OBSERVATIONS ON LONG TERM ADMINISTRATION OF GOSSYPOL ACETIC ACID.. 60() |
| Amount utilized | |
| Compound isolated | |
| Disease | GOSSYPOL ACETIC ACID WAS USED. DAILY DOSING FOR 1 YEAR (13 RECEIVED GOSSYPOL ACETIC ACID AND 10 SERVED AS CONTROLS.). THE BLOOD PICTURE, BONE MARROW, ECG, LIVER FUNCTION AND RENAL FUNCTION REMAINED NORMAL AT 6 MONTHS AND 1 YEAR. NO PATHOLOGICAL CHANGES WERE SEEN IN THE HEART, LIVER, SPLEEN, LUNGS OR KIDNEYS OF GOSSYPOL ACETIC ACID TREATED ANIMALS. SLIGHT INCREASE IN RNA IN LIVER LOBULE CENTRAL, INTERMEDIATE AND PERIPHERAL ZONES AND THERE WAS LESS LIVER GLYCOGEN. LITTLE DIFFERENCE IN ACID AND ALKALINE PHOSPHATASES IN PROXIMAL TUBULES OF THE KIDNEY BETWEEN TREATED AND CONTROL ANIMALS. A SLIGHT DECREASE IN LIPID DROPLETS IN THE ZONA GLOMERULOSA. AFTER DISCONTINUATION OF THE TREATMENT WITH GOSSYPOL ACETIC ACID, LIVER RNA AND LIVER GLYCOGEN SHOWED RECOVERY TO VARYING DEGREES. |
| Dose amount | 7.5 MG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |