Experiment 1077469
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | SANG,GW: ZHANG,YG: SHI,QX: SHEN,KY: LU,FY: ZHAO,XJ: WANG,MQ: LIU,XL: YUAN,YY:. (1980). CHRONIC TOXICITY OF GOSSYPOL AND THE RELATION TO ITS METABOLIC FATE IN DOGS AND MONKEYS.. 1() |
| Amount utilized | |
| Compound isolated | |
| Disease | DAILY DOSING FOR FOUR WEEKS. ABNORMAL HEART ELECTRICAL ACTIVITY AS REFLECTED BY ECG. BLOOD COMPOSITION,HEPATIC FUNCTION AND RENAL FUNCTIONS REMAINED NORMAL. FOUR OF SIX ANIMALS DIED WITHIN 3 MONTHS.HISTOLOGICAL EXAMS REVEALED SEVERE MYOCARDIAL DAMAGES. HISTOLOGICAL CHANGES AND CARDIAC SIGNS IN THE TWO SURVIVING ANIMALS WERE RESTORED ONE YEAR AFTER DISCONTINUING THE GOSSYPOL. |
| Dose amount | 2-5.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | DOG |
| Per unit | KG |
| Dose expression | DOSE |