Experiment 1078024
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IN RATION |
| Organism | Senecio jacobaea (ASTERACEAE) |
| Citation | MIRANDA,CL: CHEEKE,PR: SCHMITZ,JA: BUHLER,DR:. (1980). TOXICITY OF SENECIO JACOBAEA (TANSY RAGWORT) IN RATS.. 56() |
| Amount utilized | |
| Compound isolated | |
| Disease | SIGNIFICANT BODY WEIGHT LOSS AFTER 1 WEEK OF FEEDING. TOTAL SERUM PROTEIN AND ALBUMIN CONC WERE SIGNIFICANTLY DECREASED FROM 4-8 WEEKS OF TREATMENT.NECROPSY AFTER 8 WEEKS FEEDING SHOWED ENLARGED SPLEEN AND ATROPHIED THYMUS. AT 6-8 WEEKS OF FEEDING THERE WAS AN ACCUMULATION OF FLUID IN THE PERITONEAL AND THORACIC CAVITIES. HISTOPATHOLOGIC EXAMINATION OF THE LIVERS OF RATS REVEALED SWOLLEN HEPATOCYTES WITH HYPERACIDOPHILIC HOMOGENEOUS CYTOPLASM.OTHER HISTOPATHOLOGIC CHANGES ARE DESCRIBED. |
| Dose amount | 5.0 % OF DIET |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | CONC USED |
| Extract | AERIAL PARTS |
| Gender | MALE |