Experiment 1078829
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | LIU,Y: SU,SY: CHEN,XM: SHIEH,SP: ZHAO,XJ: XU,MY: ZHUANG,YZ:. (1980). ELECTRON MICROSCOPIC OBSERVATIONS OF EFFECTS OF GOSSYPOL ON CARDIAC MUSCLE AND ITS LACTATE DEHYDROGENASE AND SUCCINATE DEHYDROGENASE IN MALE MONKEYS.. 11() |
| Amount utilized | |
| Compound isolated | |
| Disease | GOSSYPOL ACETIC ACID WAS USED DAILY DOSING FOR TWO YEARS IN 3 ADULT MALE RHESUS MONKEYS. A FINE LINE,THE N-LINE,CHARACTERIZED BY ITS HIGH ELECTRON DENSITY, WAS OBSERVABLE AT BOTH SIDES OF THE Z-LINE IN THE-BAND OF CARDIAC MYOFIBRILLA. GOSSYPOL MAY INDUCE MUSCLE RELAXTION AND THUS INHIBIT CONTRACTION. INCREASED IN LYSOSOMES,DISTENTION OF ENDOPLASMIC RETICULUM,AND LOCAL ACCUMULATION,DERANGEMENT,AND SWELLING OF MITOCHONDRIA IN MYOCARDIAL FIBERS. HISTOCHEMICALLY THERE WAS AN INCREASE IN THE ACTIVITY OF LACTATE DEHYDROGENASE IN MITOCHONDRIA AND ENDOPLASMIC RETICULUM,AND SUCCINATE DEHYDROGENASE IN MITOCHONDRIA OF CARDIAC MUSCLES AFTER GOSSYPOL TREATMENT. |
| Dose amount | 5-10 MG |
| Number | 1 |
| Qualitative result | WEAK ACTIVITY |
| Animal | MONKEY |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |