Experiment 1080095
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IN RATION |
| Organism | Gossypium hirsutum (MALVACEAE) |
| Citation | REBER,EF: JONES,LP:. (1981). EFFECT OF GOSSYPOL ON RAT FERTILITY.(ABSTRACT).. 40() |
| Amount utilized | |
| Compound isolated | |
| Disease | GOSSYPOL CONTENT WAS 0.03-0.04% WITH 20% OF THE RATION COMPRISING COTTONSEED MEAL. SEXUALLY MATURE HOLTZMAN RATS(F-O) WERE FED THE DIET FOR THREE WEEKS PRIOR TO BREEDING. THE OFFSPRING (F-1), 150 MALES AND 150 FEMALES, WERE FED THE DIETS FOR 24 WEEKS DURING WHICH TIME THEY WERE BRED. ONE F-O AND 5 F-1 MALES DID NOT SIRE A LITTER. HISTOLOGICAL EXAMINATION OF THE TESTES INDICATED ACTIVE AND APPARENTLY NORMAL SPERMATOGENESIS. NO SIGNIFICANT LESIONS WERE DETECTED BY GROSS OR MICROSCOPIC EXAMINATIONS. THE MG OF FREE GOSSYPOL CONSUMED PER DAY KG OF BODY WEIGHT RANGED FROM 3.3 TO 3.8 FOR THE MALES (F-1). THEREFORE COTTONSEED CONTAINING 0.04% FREE GOSSYPOL, INCLUDING AT 20% OF THE DIET HAD NO CONTRACEPTIVE EFFECT. |
| Dose amount | 20.0 % OF DIET |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | RAT |
| Dose expression | CONC USED |
| Extract | SEEDS |
| Gender | MALE |