Experiment 1080423
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Montanoa tomentosa (ASTERACEAE) |
| Citation | MATEOS,JL: NORIEGA,L:. (1979). UTERO-EVACUANT EXTRACTS FROM PLANT SUBSTANCES.. () |
| Amount utilized | |
| Compound isolated | |
| Disease | LEAVES(2 KG) WERE COVERED WITH 10-12 LITERS OF WATER AND BOILED FOR 1 HR. THE AQUEOUS EXTRACT WAS EXTRACTED TWICE WITH ETHYL ACETATE AND TAKEN TO DRYNESS. THE RESIDUE WAS EXTRACTED WITH BOILING BENZENE FOR 15 MINUTES. THE BENZENE EXTRACTS WERE TAKEN TO DRYNESS AND THE RESIDUE WAS SUCCESSIVELY EXTRACTED WITH SEPARATE PORTIONS OF HEXANE. THE HEXANE EXTRACT WAS DRIED AND DISSOLVED IN ACETONE AND LEFT AT ROOM TEMPERATURE WITH CHARCOAL FOR 1 HR. FILTRATION, FOLLOWED BY REMOVAL OF SOLVENT FROM THE FILTRATE AFFORDED 4-6 GM OF HIGHLY ACTIVE MATERIAL. EACH OF FOUR HUMAN FEMALES WAS GIVEN AN ORAL 500 MG DOSE OF THE EXTRACT(AGES 25,25,29 AND 41) ON THE 11TH,15TH,22ND OR 24TH DAY OF THEIR CYCLES. THREE OF THE FOUR WOMEN BEGAN BLEEDING WITHIN 1-5 HR AFTER DOSING. THE FOURTH WOMAN HAD NO BLEEDING UNTIL THE 27TH DAY. IN EACH CASE SIGNIFICANT CRAMPING WAS FELT. THERE WAS A SLIGHT ELEVATION IN BODY TERMPERATURE WHICH SUBSIDED WITHIN 10 HR. |
| Dose amount | 500.0 MG |
| Number | 4 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |
| Extract | HOT H2O EXT |
| Gender | FEMALE |