Experiment 1080429
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Montanoa tomentosa (ASTERACEAE) |
| Citation | MATEOS,JL: NORIEGA,L:. (1979). UTERO-EVACUANT EXTRACTS FROM PLANT SUBSTANCES.. () |
| Amount utilized | |
| Compound isolated | |
| Disease | A CHLOROFORM EXTRACT WAS CONCENTRATED TO DRYNESS AND EXTRCTED WITH HOT ETHANOL-WATER(1:2). THE AQUEOUS-ETHANOL PHASE WAS REEXTRACTED WITH CHLOROFORM: THE CHLOROFORM LAYER WAS SEPARATED AND CONCENTRATED TO DRYNESS. THIS RESIDUE WAS DISSOLVED IN ETHER ANDD THE SOLUTION WAS WASHED WITH AQUEOUS SATURATED SOLUTION OF SODIUM BICARBONATE,5% NAOH,WATER AND DRIED OVER SODIUM SULFATE. EVAPORATION OF THE ETHR GAVE A YELLOW OIL(11.9 GM FROM 2.0 KG DRIED LEAVES). AN 11 WEEK PREGNANT WOMAN,DIAGNOSED AS CARRYING A HYDATIDIFORM MOLE WAS GIVE A SINGLE ORAL DOSE OF THE EXTRACT. THE PATIENT WAS MONITORED FOR BLOOD PRESSURE,HEART RATE AND AMNIOTIC FLUID PRESSURE. AT ABOUT 19 MINUTES AFTER ADMINISTERING THE EXTRACT SIGNIFICANT UTERINE CONTRACTIONS BEGAN. THERE WAS NO CHANGE IN BLOOD PRESSURE OR HEART RATE. THIS CONTINUED FOR A PERIOD OF 12 HRS, AT WHICH TIME THE PATIENT ABORTED. |
| Dose amount | 0.211 GM |
| Number | 10 |
| Qualitative result | ACTIVE |
| Animal | HUMAN(PREGNANT) |
| Per unit | LB |
| Dose expression | DOSE |
| Extract | CHCL3 EXT |