Experiment 1080636
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | NEIDHART,JA: LAUFMAN,LR: VAUGHN,C: MC CRACKEN,JD:. (1980). MINIMAL SINGLE-AGENT ACTIVITY OF MAYTANSINE IN REFRACTORY BREAST CANCER: A SOUTHWEST ONCOLOGY GROUP STUDY.. 64() |
| Amount utilized | |
| Compound isolated | |
| Disease | CLINICAL STUDY IN41 PATIENTS WITH ADVANCED DRUG-RESISTANT BREAST CANCER. ALL PATIENTS HAD BENN HEAVILY PRETREATED WITH CYCLOPHOSPHAMIDE, METHOTREXATE, 5-FLUOROURACIL OR DOXORUBICIN, AND 12 HAD RECIVED VINBLASTINE, MITOMYCIN C OR INVESTIGATIONAL DRUGS. ALL PATIENTS HAD AN EXPECTED SURVIVAL OF SIX WEEKS. TREATMENT WAS WITH A 5-DAY INTERMITTENT IV INFUSION REPEATED EVERY 21 DAYS. ONE PATIENT HAD A PARTIAL REGRESSION OF PULMONARY DISEASE, SEVENN HAD TRANSIENT RESPONSES OF LESS THAN 50% REDUCTION IN TUMOR OR STABLE DISEASE, AND 21 HAD PROGRESSIVE DISEASE. 12 PATIENTS DID NOT COMPLETE ONE FULL CYCLE OF THERAPY. TOXIC EFFECTS(VOMITING,DIARRHEA,ILEUS,LETHARGY AND ALTERED MENTATION) WERE CONSIDERABLE. FURTHER EVALUATION IN COMBINATION CHEMOTHERAPY WAS RECOMMENDED. |
| Dose amount | 0.5 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | FEMALE |