| Disease | CLINICAL STUDY IN 17 HEALTHY VOLUNTEERS,AGES 25-44 YEARS,FOR 35-42 DAYS. DAILY DOSING.
SPERM COUNTS AT BEGINNING OF STUDY(BEFORE GOSSYPOL) WERE 99,760.000/ML:AFTER ONE WEEK,3,410,000:AFTER 3-6 WEEKS,57,000. SPERM MOTILITY BEFORE GOSSYPOL WAS 78.8%:AFTER 1-3 WEEKS,0%:AFTER 3-6 WEEKS,0%.
GASTROENTERITIS SYMPTOMS BY THE END OF THE STUDY.
DECREASED APPETITE(7 SUBJECTS),FATIGUE(5 SUBJECTS),DRYNESS OF MOUTH(5 SUBJECTS),DIARRHEA(4 SUBJECTS),SLIGHT ELEVATION OF SGPT(4 SUBJECTS),INCREASED APPETITE(3 SUBJECTS):UPPER ABDOMINAL DISCOMFORT(3SUBJECTS),TENDENCY TO SLEEPINESS(3 SUBJECTS)
ALSO,DIZZINESS(2 SUBJECTS),CONSTIPATION (1 SUBJECT),EDEMA OF EYELIDS(1 SUBJECT),SEEMINGLY DECREASED LIBIDO AND POTENCY(1 SUBJECT),INCREASE IN URINARY PROTEIN FROM TRACE TO 1+(1 SUBJECT).
ALSO,DEPRESSION OF SERUM POTASSIUM LEVEL FROM 4.80 TO 3.50 MMOL/ML.
ALL REACTIONS WERE SELF-LIMITING OR WERE REVERSIBLE AFTER CESSATION OF GOSSYPOL. A FEW REQUIRED SYMPTOMATIC TREATMENT. |