Experiment 1080667
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV BOLUS |
| Organism | Empty organism |
| Citation | ROSENTHAL,S: HARRIS,DT: HORTON,J: GLICK,JH:. (1980). PHASE II STUDY OF MAYTANSINE IN PATIENTS WITH ADVANCED LYMPHOMAS: AN EASTERN COOPERATIVE ONCOLOGY GROUP PILOT STUDY.. 64() |
| Amount utilized | |
| Compound isolated | |
| Disease | A PHASE II CLINICAL STUDY IN PATIENTS WITH ADVANCED LYMPHOMAS(HODGKIN'S DISEASE,STAGE III OR IV). ADMINISTRATION WAS DAILY FOR 3 CONSECUTIVE DAYS,WITH EACH TREATMENT CYCLE REPEATED AT 3-WEEK INTERVALS 3/31 PATIENTS SHOWED PARTIAL RESPONSES(10%). TREATMENT WAS DISCONTINUED IN THE THREE RESPONDERS AFTER 3-4 CYCLES EVEN THOUGH RESPONSED WERE CONTINUING. IN TWO CASES,THE PATIENTS REFUSED FURTHER MAYTANSINE BECAUSE OF TOXIC EFFECTS. TOXIC EFFECTS WERE MAINLY PARESTHESIAS,DIARRHEA,NAUSEA,AND VOMITING. HEMATOLOGICAL TOXICITY WAS MINIMAL. NO APPARENT HEPATOTOXIC EFFECTS. CONCLUSION WAS THAT MAYTANSINE WAS NOT WARRENTED FOR FURTHER STUDIES IN LYMPHOMA PATIENTS. |
| Dose amount | 0.5 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |