Experiment 1080958
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Daphne genkwa (THYMELAEACEAE) |
| Citation | DING,GS:. (1980). TRIALS OF SOME CHINESE MEDICINAL HERBS.. 1980() |
| Amount utilized | |
| Compound isolated | |
| Disease | DAILY DOSING FOR 6 DAYS,THEN 50 MCG/KG FOR 3 DAYS,THEN 100 MCG/KG. DEATH OF ONE ANIMAL AT THE LAST DOSE. NO OBVIOUS CHANGES IN BLOOD RCB,WBC,HEMOGLOBIN,SGPT,TTT,NPN,CREATINE,URIC ACID AND ECG ON THE DAY BEFORE THE LAST(LETHAL)DOSE. DEATH WAS DUE TO VENTRICULAR FIBRILLATION ABOUT 4 HOURS AFTER THE LAST DOSE. MICROSCOPIC DEGENERATIVE LESIONS WERE SEEN IN HEART,LIVER,KIDNEY AND ADRENAL CORTEX. |
| Dose amount | 20.0 MCG |
| Number | 6 |
| Qualitative result | ACTIVE |
| Animal | MONKEY(PREGNANT) |
| Per unit | KG |
| Dose expression | DOSE |