Experiment 1080959
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Daphne genkwa (THYMELAEACEAE) |
| Citation | DING,GS:. (1980). TRIALS OF SOME CHINESE MEDICINAL HERBS.. 1980() |
| Amount utilized | |
| Compound isolated | |
| Disease | DAILY DOSING FOR 6 DAYS,THEN 50 MCG/KG FOR 3 DAYS,THEN 100 MCG/KG FOR 3 DAYS,THEN 240 MCG/KG FOR ONE DAY. ONE MONKEY DIED ON THE LAST DOSE. NO OBVIOUS CHANGES IN BLOOD RBC,WBC,HEMOBLOBIN,SGPT,TTT,NPN,CREATING,URIC ACID AND ECG ON THE DAY BEFORE THE LAST(LETHAL) DOSE. DEATH WAS DUE TO VENTRICULAR FIBRILLATION ABOUT 4 HOURS AFTER THE LAST DOSE. MICROSCOPIC DEGENERATIVE LESIONS WERE SEEN IN HEART,LIVER,KIDNEY AND ADRENAL CORTEX. |
| Dose amount | 20.0 MCG |
| Number | 7 |
| Qualitative result | ACTIVE |
| Animal | MONKEY(PREGNANT) |
| Per unit | KG |
| Dose expression | DOSE |