| Disease | GOSSYPOL ACETIC ACID(GOSSYPOL ACETATE,POLYSCIENCE CO.,WARRINGTON,PA.)WAS USED IN THE STUDY. NO DEGREE OF PURITY STATED. TEN DAY OLD ANIMALS WERE USED.
IN 30 DAY FORCE-FED ANIMALS,LIQUID DROPLETS FILLED THE LEYDIG CELLS AND THE SEMINIFEROUS TUBULES EITHER LACKED OR EXHIBITED TRIVIAL LUMINA.
DAILY FORCE-FEEDING OF GOSSYPOL ACETATE FOR 10-30 DAYS. ANIMALS SACRIFICED AND TESTES FIXED FOR SECTIONING.
SPERMATOGENESIS FAILED TO PROCEED BEYOND THE PAHYTENE SPERMATOCYTE STAGE.PACHYTENE SPERMATOCUTES WERE RARE.
SMALL SERTOLI CELLS,RICH IN LIPID DROPLETS,DISCLOSED ROTUND NUCLEI WITH ABUNDANT CLUMPS OF CHROMATIN CLOSELY OPPOSED TO THE NUCLEAR ENVELOPE.
SERTOLI-CELL JUNCTIONAL SPECIALIZATIONS UBIQUITOUSLY REVEALED SHORT,ITERRUPTED,MEANDERING JUNCTIONAL STRANDS.
IT WAS CONCLUDED THAT GOSSYPOL-FEEDING OF THE NEONATE INTERFERES WITH SERTOLI-CELL JUNCTION FORMATIN,INITIATION OF SPERMATOGENESIS, AND PRESUMABLY LEGYDIG-CELL FUNCTION |