Experiment 1081539
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | PRASAD,MRN: DICZFALUSY,E:. (1982). GOSSYPOL.. 5() |
| Amount utilized | |
| Compound isolated | |
| Disease | GOSSYPOL ACETIC ACID WAS USED. DAILY DOSING FOR 120 DAYS FOLLOWED BY 20 MG EVERY OTHER DAY FOR UP TO 1 YEAR. THIS WAS A STUDY IN BRAZIL IN 1981 INVOLVING EIGHT MEN WITH NORMAL SPERM COUNT AND MOTILITY. SPERM MOTILITY WAS SIGNIFICANTLY REDUCED IN ALL SUBJECTS AT THE END OF THE 1ST MONTH OF TREATMENT. EJACULATES WERE AZOOSPERMIC OR NEAR AZOOSPERMIC AFTER 90 DAYS OF TREATMENT AND ARREST OF SPERMATOGENESIS WAS MAINTAINED. NO SIGNIFICANT CHANGES IN SEMEN VOL. TESTOSTERONE LEVEL,BLOOD CHEMISTRY AND SERUM K+ LEVELS WERE NORMAL THROUGHOUT THE TREAMMENT.NONE OF THE 8 SUBJECTS REPORTED LOSS OF LIBIDO OR POTENCY. NO SIGNIFICANT INFLUENCE ON TESTICULAR RESPONSE EITHER TO LHRH OR HCG. |
| Dose amount | 20.0 MG |
| Number | 5 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |
| Gender | MALE |