Experiment 1082867
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Empty organism |
| Citation | SHI,QX: ZHANG,YG: YUAN,YY:. (1981). STUDIES ON ANTIFERTILITY EFFECT OF GOSSYPOL.II. ANTIFERTILITY EFFECTS ON MALE RATS.. 27() |
| Amount utilized | |
| Compound isolated | |
| Disease | GOSSYPOL ACETIC ACID WAS USED DAILY DOSING FOR FIVE WEEKS PRODUCED AN ANTIFERTILITY EFFECT LASTING FOR 5-6 WEEKS AFTER CESSATION OF THE DRUG. SEMINIFEROUS EPITHELIUM DAMAGE WAS DEPENDENT ON THE DOSE AND DURATION OF ADMINISTRATION. THE NUMBER OF EXFOLIATED TESTIS CELLS RETURNED TO A MAXIMUM VALUE ABOUT ONE WEEK AFTER CESSATION OF THE DRUG. SPERMATIDS AND SPERMATOCYTES WERE EXTREMELY SENSITIVE TO THE ACTION OF GOSSYPOL THE SENSITIVITY SEQUENCE FOR LOSS OF SPERM ACTIVITY WAS IN THE ORDER: CAUDA,EPIDIDYMIS,CORPUS AND CAPUT. THE SENSITIVITY SEQUENCE FOR THE RESTORATION OF SPERM ACTIVITY WAS IN THE ORDER: CAPUT, EPIDIDYMIS,CORPUS AND CAUDA. |
| Dose amount | 12.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |