Experiment 1082945

Details

PropertyValue
Pharmacology
OrganismEmpty organism
CitationPANG,SN: LIN,XY: LIU,ZL: SHEN,HP: DAI,RX:. (1980). AN OBSERVATION ON THE LIVER CELLS OF THE RAT AFTER TREATMENT WITH GOSSYPOL IN VIVO AND IN VITRO.. 13()
Amount utilized
Compound isolated
DiseaseLIVER CELLS OF YOUNG RATS ABOUT 20 DAYS AFTER BIRTH WERE USED. REMARKABLE INJUROUS EFFECTS SIMILAR TO THOSE PRODUCED WHEN LARGE DOSES OF GOSSYPOL ARE ADMINISTERED IN VIVO. THE DEGREE AND EXTENT OF LIVER DAMAGE IS RELATED TO THE DOSE AND DURATION OF EXPOSURE. LIVER CELLS ARE MORE SENSITIVE TO THE EFFECTS OF GOSSYPOL IN VITRO THAN IN VIVO. HOWEVER, THEY ARE LESS SENSITIVE TO GOSSYPOL THAN SPERM CELLS, ESPECIALLY SPERMATIDS IN LATER MATURATION STAGES.
Dose amount20.0 MCG
Number2
Qualitative resultACTIVE
AnimalRAT
Per unitML
Dose expressionCONC USED
GenderMALE