Experiment 1083954
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Empty organism |
| Citation | BOZEK,SA: JENSEN,DR: TONE,JN:. (1981). SCANNING ELECTRON MICROSCOPIC STUDY OF SPERMATOZOA FROM GOSSYPOL-TREATED RATS.. 219() |
| Amount utilized | |
| Compound isolated | |
| Disease | GOSSYPOL ACETIC ACID WAS USED. DAILY DOSING FOR NINE WEEKS.ANIMALS SACRIFICED AND SPERM REMOVED FROM CAUDAE EPIDIDYMIDIS FOR EXAMINATION BY ELECTRON MICROSCOPY. IN TREATED ANIMALS,SPERM PELLETS WERE SMALLER.SPERMATOZOA EXHIBITED A WRINKLED,DISORGANIZED CELL SURFACE OF BOTH HEAD AND TAIL REGIONS. SPERMATOZOA WITH MALFORMED HEAD AND DECAPITATE SPERMATOZOA WERE OBSERVED. CELL MEMBRANE APPEARED TO BE MISSING FROM SEGMENTS OF THE TAIL MIDPIECE AND PRINCIPAL PIECE. A LARGE,VESICULAR CYTOPLASMIC DROPLET IN THE MIDPIECE OCCURRED AT HIGH FREQUENCY AMONG THE EXPERIMENTAL SPERMATOZOA AND WAS LOCATED AT VARIABLE LOCI ALONG THE MIDPIECE.SPERMATOZOA WITH LOOPED TAILS WERE OBSERVED. |
| Dose amount | 40.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |