Experiment 1085360
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Empty organism |
| Citation | HADLEY,MA: LIN,YC: DYM,M:. (1981). EFFECTS OF GOSSYPOL ON THE REPRODUCTIVE SYSTEM OF MALE RATS.. 2() |
| Amount utilized | |
| Compound isolated | |
| Disease | GOSSYPOL ACETIC ACID WAS USED(SIGMA CHEMICALS:GREATER THAN 98% PURE:M.P.178-180 C) DAILY DOSING FOR 5 WEEKS SPERM IN THE EJACULATE WERE IMMOBILE AND REDUCED IN NUMBER ULTRASTRUCTRAL EXAMINATION OF EPIDIDYMAL SPERMATOZOA REVEALED DEGENERATION IN THE TAIL REGION, PARTICULARLY IN THE MITOCHONDRIAL SHEATH OF THE MIDDLE PIECE.WITHIN THE SEMINIFEROUS EPITHELIUM,LATE SPERMATIDS DISPLAYED A SIMILAR DEGENERATION,BUT NOT AS BAD. AFTER A 6 WEEK RECOVERY PERIOD,NORMAL FERTILITY WAS RE-ESTABLISHED AND NORMAL LITTERS WERE PRODUCED. SPERM MOTILITY AND NUMBER,SERUM TESTOSTERONE AND LH LEVELS, AND SPERM STRUCTURE ALL RETURNED TO NORMAL |
| Dose amount | 30.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |