Experiment 1087472

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismEmpty organism
CitationSCHMOLL,HJ: NIEDERLE,N: ACHTERRATH,W:. (1981). ETOPOSIDE(VP 16-213) - A PODOPHYLLOTOXINDERIVATIVE WITH HIGH ANTITUMOR ACTIVITY.. 59()
Amount utilized
Compound isolated
DiseaseUSUAL DOSE IS 80-120 MG/SQ METER ON 3-5 CONSECUTIVE DAYS AND REPITITION AFTER 21 DAYS. SIDE EFFECTS INCLUDE DOSE-LIMITING BONE MARROW TOXICITY,NAUSEA,VOMITING,FEVER,HYPOTENSION,PHLEBITIS,MUCOSITIS,NEUROPATHY,CARDIOTOXICITY AND ALOPECIA. ETOPOSIDE IS ONE OF THE MOST ACTIVE SINGLE AGENTS IN SMALL CELL BRONCHUS CARCINOMA WITH A REMISSION RATE OF 37% AND IS VERY ACTIVE IN TESTICULAR CARCINOMA(37%),AMML(35%),CHORIOCARCINOMA(35%) AND NEUROBLASTOMA(29%). THE MECHANISM OF ACTION AND A REVIEW OF ACTIVITY AGAINST ANIMAL TUMORS ARE INCLUDED.
Dose amountVAR
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE