Experiment 1087486
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | YAP,HY: BLUMENSCHEIN,GR: BODEY,GP: HORTOBAGYI,GN: BUZDAR,AU: DI STEFANO,A:. (1981). VINDESINE IN THE TREATMENT OF REFRACTORY BREAST CANCER: IMPROVEMENT IN THERAPEUTIC INDEX WITH CONTINUOUS 5-DAY INFUSION.. 65() |
| Amount utilized | |
| Compound isolated | |
| Disease | 60 PATIENTS WITH METASTATIC BREAST CANCER REFRACTORY TO PRIOR DOXORUBICIN COMBINATIONS WERE RANDOMIZED BY PERFORMANCE STATUS,DOMINANT DISEASE SITE AND NUMBER OF INVOLVED ORGAN SITES TO RECEIVE VINDESINE, EITHER AS A BOLUS INJECTION OF 3-4 MG/SG M I.V. EVERY 10-14 DAYS OR AS A CONTINUOUS I.V. INFUSION EVERY 21 DAYS. OF THE 25 EVALUABLE PATIENTS WHO RECEIVED CONTINUOUS INFUSIONS,7 ACHIEVED A PARTIAL RESPONSE AND 11 HAD A STABLE DISEASE STATE. 13 PATIENTS FAILING TO RESPOND TO I.V. BOLUS WERE GIVEN CONTINUOUS INFUSIONS. OF THESE, 11 WERE EVALUABLE AND 4 HAD PARTIAL REMISSIONS. |
| Dose amount | 3-4.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |