Experiment 1087487
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | COBLEIGH,MA: WILLIAMS,SD: EINHORN,LH:. (1981). PHASE II STUDY OF VINDESINE IN PATIENTS WITH METASTATIC BREAST CANCER.. 65() |
| Amount utilized | |
| Compound isolated | |
| Disease | 26 PATIENTS WITH FAR-ADVANCED,REFRACTORY BREAST CANCER WERE TREATED I.V. WITH VINDESINE IN A PHASE II CLINICAL STUDY. IN 21 EVALUABLE PATIENTS THERE WERE SIX PARTIAL REMISSIONS. FOUR PATIENTS WHO DID NOT RESPOND WERE GIVEN VINDESINE BY CONTINUOUS INFUSION EVERY OTHER WEEK. NONE RESPONDED. FIVE OF THE SIX RESPONDERS HAD HAD DISEASE PROGRESSION ON OTHER VINCA ALKALOIDS. LEUKOPENIA AND NEUROMUSCULAR TOXICITY WERE DOSE-LIMITING. |
| Dose amount | 3.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | FEMALE |