Experiment 1088014
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | COOPER,IA: DING,JC: GUNZ,FW: VINCENT,PC: HERMANN,RP: MATTHEWS,JRD: STEPHENS,EJW: PENINGTON,DG: BURNS,WI: PITNEY,WR: SAGE,RD: DALE,B: MATHEWS,JP: MOTTE:. (1982). COMPARISON OF THE USE OF TENIPOSIDE AND VINCRISTINE IN COMBINATION CHEMOTHERAPY FOR NON-HODGKIN'S LYMPHOMA.. 66() |
| Amount utilized | |
| Compound isolated | |
| Disease | A TOTAL OF 164 PATIENTS WITH NON-HODGKIN'S LYMPHOMA WERE RANDOMIZED TO RECEIVE CYCLES OF TREATMENT EVERY 3 WEEKS WITH TENIPOSIDE + CYCLOPHOSPHAMIDE (I.V.) + PREDNISOLONE (P.O.) OR LEUROCRISTINE + CYCLOPHOSPHAMIDE (I.V.) + PREDNISOLONE. THE SECOND REGIMEN PRODUCED 54% COMPLETE REMISSIONS AND 19% PARTIAL REMISSIONS BUT SEVERE NEUROTOXICITY WAS SEEN IN 12% OF PATIENTS AND MODERATE NEUROTOXICITY IN 36%. |
| Dose amount | 1.4 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |