Experiment 1088040
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | TONG,SM: ZHOU,XH: ZHOU,YX:. (1982). HUMAN ANTIFERTILITY EFFECT OF GOSSYPOL.CYTOLOGIC OBSERVATION OF SEMEN.. 95() |
| Amount utilized | |
| Compound isolated | |
| Disease | ENTERIC COATED GOSSYPOL TABLETS WERE USED IN THE STUDY 8 MEN, EXCEPT 1 WHO HAD RECEIVED GOSSYPOL FOR 1 MONTH AFTER CYSTECTOMY,WERE GIVEN THE ENTERIC TABLET FORM UNTIL A SPERM COUNT OF LESSTHAN 4 MILLION WAS ATTAINED. THEN A MAINTENANCE DOSE OF 15 MG TWICE WEEKLY WAS GIVEN DUE TO A LOWER ABSORBTION RATE OF ENTERIC COATED TABLETS,SOME SUBJECTS HAD TO CHANGE TO GOSSYPOL ACETIC ACID AFTER 4-5 MONTHS ADMINISTRATION. ANTISPERMATOGENIC EFFECT USING ENTERIC COATED GOSSYPOL WAS LOWER THAN IN SUBJECTS GIVEN GOSSYPOL FORMIC ACID. DATA FROM LIGHT AND ELECTRON MICROSCOPIC STUDIES OF SPERM SHOWEXPRESSION DOSE=69% OF SPERM WERE ABNORMAL. |
| Dose amount | 15.0 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |
| Gender | MALE |