Experiment 1088888
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | COUTINHO,EM:. (1982). CLINICAL STUDIES WITH GOSSYPOL.. 3(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | STUDY IN 8 MEN FOR PERIODS OF 6-12 MONTHS. DOSING WAS DAILY FOR 4 MONTHS FOLLOWED BY 20 MG ON ALTERNATE DAYS. REDUCTION IN SPERM NUMBER OCCURRED AFTER 45 DAYS AND AZOOSPERMIA AT THE END OF 4 MONTHS OF TREATMENT. NO CHANGE IN SEMEN VOLUME WAS DETECTED. THE RESPONSE TO LH-RH AND HCG WAS NORMAL DURING THE TREATMENT TESTOSTERONE LEVELS REMAINED WITHIN THE NORMAL RANGE. NONE OF THE SUBJECTS REPORTED LOSS OF LIBIDO OR POTENCY. BLOOD CHEMISTRY WAS NORMAL. THERE WAS NO SIGNIFICANT CHANGE IN BLOOD PRESSURE OR BODY WEIGHT. REVERSIBILITY WAS FASTER IN MEN WHO TOOK THE DRUG FOR SHORT PERIODSOF TIME. |
| Dose amount | 20.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |
| Gender | MALE |