| Disease | GOSSYPOL WAS RELATIVELY STABLE IN ORGANIC SOLVENTS,SUCH AS ETHANOL AND DIMETHYL SULFOXIDE, AS EVIDENCED BY TLC STUDIES. A MINOR COMPONENT WAS DETECTED AFTER 1 WEEK OF STORAGE IN THE DARK, AT ROOM TEMPERATURE,OR AT -20C.
GOSSYPOL IN 0.1 CITRATE, PH 4.5 WAS RELATIVELY STABLE,WHEREAS IT WAS DECOMPOSED WITH TIME IN A NEUTRAL AQUEOUS SOLUTION (50 MICROMOLS PHOSPHATE BUFFER,PH7.0.
4 MAJOR DECOMPOSITION PRODUCTS OF GOSSYPOL WERE IDENTIFIED BY TLY WITH RF VALUES OF 0.54, 00.34, 0.27 AND 0.12, RESPECTIVELY,WHEN THESOLVENT SYSTEM OF BENZENE:EHTYL ACETATE:ACETIC ACID(84:13:3) WAS EMPLOYED.
GOSSYPOL WAS DECOMPOSED FASTER AT PH 8.5 THA AT PH 7.0. IT WASALSO SHOWN THAT GOSSYPOL WAS DECOMPOSED INTO 6 MAJOR PRODUCTS AFTER 18HOURS OF INCUBATION IN 0.05 M BICARBONATE SOLUTION, PH 8.5,WHEN ANALYZED BY HPLC. |