Experiment 1089191
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Empty organism |
| Citation | YE,WS: LIU,Y: SHAO,TS: LIU,ZH: YOU,MM: GUO,Y: SHIEH,SP:. (1982). OBSERVATIONS OF THE EFFECT OF GOSSYPOL ON PROTEIN AND NUCLEIC ACID SYNTHESIS IN SPERMATOGENIC CELLS OF RAT TESTIS IN VIVO AND IN VITRO.. 13(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | DAILY DOSING FOR 3-6 WEEKS DID NOT NIHIBIT LYSINE-3H OR URIDINE-3H FROM BEING INCORPORATED INTO SPERMATOGENIC CELLS. THE ARGININE-3H LABELLING OF SPERMATIDS OF 11-19 STAGES WAS DECREASED. IT WAS CONCLUDED THAT SPERMATIDS OF LATE STAGE WHICH INCORPORATED ARGININE-3H SELECTIVELY FOR THE SYNTHESIS OF ARGININE-RICH HISTONESWERE MOST SENSITIVE TO THE ACTION OF GOSSYPOL. THE RELATIONSHIP BETWEEN INTERFERENCES WITH ARGININE-RICH HISTONE SYNTHESIS AND LOSS OF SPERM FERTILIZIN CAPACITY IS DISCUSSED. |
| Dose amount | 30.0 MG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |