Experiment 1089684
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | TSO,WW: LEE,CS:. (1982). GOSSYPOL UNCOUPLING OF RESPIRATORY CHAIN AND OXIDATIVE PHOSPHORYLATION IN EJACULATED BOAR SPERMATOZOA.. 25() |
| Amount utilized | |
| Compound isolated | |
| Disease | THE TEST COMPOUND WAS DISSOLVED IN 0.5M NAOH IMMEDIATELY BEFORE USE. GOSSYPOL UNCOUPLED THE RESPIRATORY CHAIN FROM OXIDATIVE PHOSPHOSPHORYLATION,THIS UNCOUPLING APPEARED TO BE NEITHER ANIMAL-SPECIFIC NOR TISSUE SPECIFIC. SIMULTANEOUSLY, GOSSYPOL ALSO INHIBITS MANY OTHER. BIOCHEMICAL REACTIONS,SUCH AS THE GONAD-SPECIFIC LHD-X TESTOSTERONE PRODUCTION BY LEYDIG CELLS. THIS SUGGESTS THAT THE UNCOUPLING ACTION OF GOSSYPOL MAY NOT BE THE PRIMARY CAUSE OF CONTRACEPTION. IT DOES NOT RULE OUT THE POSSIBILITY THAT A REDUCTION IN ENERGY SUPPLY,ESPECIALLY IN THE EARLY. DEVELOPMENTAL PROCESS, MIGHT BE VITAL TO SPERMATOGENESIS. |
| Dose amount | 0.032 MILLIMOLS |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | BOAR |
| Dose expression | CONC USED |
| Gender | MALE |