Experiment 1090556
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Empty organism |
| Citation | FAI,YY: LIANG,DT: GOU,Y: LIU,Y: GOR,XY: CHOW,CH: XUE,SP:. (1982). EFFECT OF GOSSYPOL ON THE ACTIVITY OF RENAL CELL MEMBRANE SODIUM, POTASSIUM ATPASE OF RATS AND GUINEA PIGS.. 2() |
| Amount utilized | |
| Compound isolated | |
| Disease | ADMINISTRATION TO RATS IN INCREASING DOSAGE HAD NO EFFECT ON RENAL CELL MEMBRANE NA-K-ATPASE BOUND TO OUABAIN. SIMILAR RESULTS WERE OBTAINED WITH GUINEA PIGS. HOWEVER, GUINEA PIG TOTAL ISOLATED RENAL CELL MEMBRANE NA-K-ATPASE ACTIVITY DECREASED WITH INCREASING DOSAGE OF GOSSYPOL. A LOW K INTAKE POTENTIATES THE GOSSYPOL-INDUCED DECREASE IN NA-K-ATPASE ACTIVITY AND RENAL K LOSS IS DISCUSSED. DOSES EMPLOYED WERE 5.0, 10.0, AND 15.0 MG/KG FOR UP TO 56 DAYS. |
| Dose amount | VAR |
| Number | 2 |
| Qualitative result | INACTIVE |
| Animal | RAT |
| Dose expression | DOSE |
| Gender | MALE |