Experiment 1090564
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Empty organism |
| Citation | YE,WS: LIU,Y: SHAO,TS: LIU,ZH: YOU,MM: GUO,Y: SHIEH,SP:. (1982). OBSERVATIONS OF THE GOSSYPOL EFFECTS ON THE PROTEIN AND NUCLEIC ACID SYNTHESIS IN SPERMATOGENIC CELLS OF RAT TESTIS IN VIVO AND IN VITRO.. 13() |
| Amount utilized | |
| Compound isolated | |
| Disease | ANIMALS RECEIVED DAILY DOSES OF GOSSYPOL FOR 3,4,5 AND 6 WEEKS CONSECUTIVELY. TESTES WERE RECOVERED 2 HOURS AFTER INTRATESTICULAR INJECTION OF 3H-ARGENINE,3H-LYSINE OR 3H-URIDINE, RESPECTIVELY AND PROCESSED FOR AUTORADIOGRAPHY. ACTIVITY AND FREQUENCY OF LABELING OF 3H-ARGININE IN SPERMATIDS OF 11-19 STAGES WERE SHOWN TO BE OBVIOUSLY DECREASED. THIS SHOWS THAT THE SPERMATIDS OF LATE STAGES WHICH INCORPORATE 3H-ARGININE SELECTIVELY FOR THE SYNTHESIS OF ARGININE-RICH HISTONES WERE THE MOST SENSITIVE TO GOSSYPOL. |
| Dose amount | 30.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |