Experiment 1090630
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ROUTE NOT GIVEN |
| Organism | Butea monosperma (FABACEAE) |
| Citation | DIXIT,VP: AGARWAL,M: BHARGAVA,SK: GUPTA,RS: JAIN,GC:. (1981). EFFECTS OF BUTEA MONOSPERMA SEED EXTRACT FRACTION (BUTIN) ON THE TESTICULAR FUNCTION OF RAT, DOG AND PRESBYTIS MONKEY.. 17() |
| Amount utilized | |
| Compound isolated | |
| Disease | INHIBITION OF SPERMATOGENESIS WAS ACHIEVED AFTER CHRONIC ADMINISTRATION OF THE EXTRACT. SEMINIFEROUS EPITHELIUM WAS DEPLETED OF SPERMATOGENIC ELEMENTS: ONLY SPERMATOGONIA AND SPERMATOCYTES WERE SEEN. THE EPIDIDYMAL LUMINA WERE DEVOID OF SPERMATOZOA IN TREATED ANIMALS. THERE WAS A SIGNIFICANT DECREASE IN PROTEIN,SIALIC ACID,ACID PHOSPHATASE AND GLYCOGEN CONTENTS IN THE TESTIS AND EPIDIDYMIS AFTER TREATMENT WITH THE EXTRACT. TOTAL CHOLESTEROL OF THE TESTIS WAS HIGH. BLOOD SUGAR,HB AND HEMATOCRIT VALUES WERE WITHIN NORMAL RANGE. SERUM GPT WAS DECREASED. SERUM PHOSPHATASE, CHOLESTEROL,TRIGLYCERIDES,NONESSENTIAL FATTY ACIDS AND SERUM PROTEIN LEVELS DID NOT CHANGE. |
| Number | 3 |
| Qualitative result | ACTIVE |
| Animal | MONKEY(PRESBYTIS) |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |
| Gender | MALE |