Experiment 1091735

Details

PropertyValue
Pharmacology
Administration routeGASTRIC INTUBATION
OrganismSmilax species (LILIACEAE)
CitationWANG,WH: YU,JH: ZHOU,ZR: CHEN,SW: ZHAO,NJ: LI,YQ:. (1982). ANTAGONISTIC EFFECT OF SMILAX SP. ON GOSSYPOL TOXICITY.. 7(1)
Amount utilized
Compound isolated
DiseaseANIMALS WERE DOSED ONCE DAILY FOR TWO DAYS WITH THE SMILAX EXTRACT PRIOR TO CHALLENGE WITH A TOXIC DOSE OF GOSSYPOL ON THE THIRD DAY. THIS WAS FOLLOWED BY AN ADDITIONAL DOSE OF 650 MG/KG OF THE PLANT EXTRACT. THE DEATH RATES WERE RECORDED THREE DAYS AFTER GOSSYPOL ADMINISTRATION. DOSE IS EXPRESSED IN TERMS OF WEIGHT OF THE CRUDE DRUG EQUIVALENT REPRESENTED IN THE AMOUNT ADMINISTERED TO THE ANIMALS. AT THIS DOSE LEVEL 4/10 MICE DIED,RELATIVE TO 14/20 IN THE CONTROL GROUP THAT RECEIVED ONLY THE TOXIC DOSE OF GOSSYPOL.
Dose amount0.5 GM
Number1
Qualitative resultINACTIVE
AnimalMOUSE
Per unitANIMAL
Dose expressionDOSE
ExtractHOT H2O EXT
GenderMALE