Experiment 1091741
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Smilax species (LILIACEAE) |
| Citation | WANG,WH: YU,JH: ZHOU,ZR: CHEN,SW: ZHAO,NJ: LI,YQ:. (1982). ANTAGONISTIC EFFECT OF SMILAX SP. ON GOSSYPOL TOXICITY.. 7(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | ANIMALS WERE DOSED ONCE DAILY FOR TWO DAYS WITH THE SMILAX EXTRACT PRIOR TO CHALLENGE WITH A TOXIC DOSE OF GOSSYPOL ON THE THIRD DAY. THIS WAS FOLLOWED BY AN ADDITIONAL DOSE OF 650 MG/KG OF THE PLANT EXTRACT. THE DEATH RATES WERE RECORDED 3 DAYS AFTER GOSSYPOL ADMINISTRATION. DOSE IS EXPRESSED IN TERMS OF WEIGHT OF THE CRUDE DRUG EQUIVALENT REPRESENTED IN THE AMOUNT ADMINISTERED TO THE ANIMALS. AT THIS DOSE LEVEL 9/10 ANIMALS DIED, RELATIVE TO 20/20 DEATHS IN THE CONTROL GROUP RECEIVING ONLY A TOXIC DOSE OF GOSSYPOL. DOSING WITH 8 MG/KG OF FERROUS SULFATE SIGNIFICANTLY INHIBITED DEATHS IN GOSSYPOL-TREATED ANIMALS. |
| Dose amount | 0.5 ML |
| Number | 7 |
| Qualitative result | INACTIVE |
| Animal | MOUSE |
| Per unit | ANIMAL |
| Dose expression | DOSE |
| Extract | POLYSACCHARIDE FRACTION |
| Gender | MALE |