Experiment 1096372
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | MARZO,A: GHIRARDI,P: PARENTI,MA: MERLO,L: MARCHETTI,G: CAVALCA,L: OMBONI,E: PIGNATARO,T: LIGRESTI,A:. (1981). PHARMACOKINETICS OF A COMBINATION OF RAUBASINE, DIHYDROERGOCRISTINE AND DIHYDROERGOTAMINE IN DOGS AND HUMAN BEINGS.. 36() |
| Amount utilized | |
| Compound isolated | |
| Disease | LEVELS OF THE DRUG WERE HIGHER IN THE HEART,LIVER,KIDNEYS,INTESTINAL WALL AND INTESTINAL CONTENTS THAN IN THE BRAIN,SKELETAL MUSCLE,SKIN AND PLASMA. UNUSUAL COOPERATIVE BINDING WITH PLASMA PROTEIN WHICH ALLOWS A HIGH PERCENTAGE OF AJMALICINE TO BIND PROTEIN WHEN THE PLASMA CONCENTRATION INCREASES. PEAK PLASMA LEVEL WAS ABOUT 1-2 HOURS AFTER ADMINISTRATION. EXCRETION WAS ALMOST EXCLUSIVELY VIA THE BILE. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | DOG |
| Dose expression | DOSE |