Experiment 1099205
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Coptis teeta (RANUNCULACEAE) |
| Citation | WONG,HB:. (1979). EFFECTS OF HERBS AND DRUGS DURING PREGNANCY AND LACTATION.. 21(3/4) |
| Amount utilized | |
| Compound isolated | |
| Disease | THIS IS AN ACCOUNT IN A REVIEW ARTICLE,POSSIBLY CONCERNING THE TITLE PLANT,ALTHOUGH IT IS NOT MENTIONED BY NAME. THE AUTHOR ONLY REPORTS ON EFFECTS OF "THESE HERBS", WHEN 14 DIFFERENT HERBS ARE INCLUDED IN THE REVIEW. "HERE,SPECIAL STUDIES HAVE BEEN CARRIED OUT BY ME IN 1966(WONG,HB:BULL.K.K.HOSPITAL 5:1,1966) WHEN 136 GLUCOSE-6-PHOSPHATE DEHYDROGENASE-DEFICIENT NEWBORN BABIES IN K.K.HOSPITAL WERE OBSERVED DAILY FOR SEVERE JAUNDICE. THE MOTHERS WERE INTERVIEWED WITH REGARD TO WHETHER THEY TOOK "THESE HERBS" OR NOT DURING LATE PREGNANCY". OF THE 136 BABIES, 102 GAVE A POSITIVE HISTORY AND 34 DID NOT. IT CAN THUS BE SEEN THAT THREE TIMES AS MANY MOTHERS TOOK THESE PRESCRIPTIONS. THE NUMBERS OF BABIES WITH SEVERE JUANDICE IN THE TWO GROUPS WERE AS FOLLOWS: MOTHERS TOOK HERBS, 22/102 G-6-PD DEFICIENT BABIES: MOTHERS DID NOT TAKE HERBS, 2/34 6-G-PD DEFICIENT BABIES. THE DIFFERENCE WAS STATED TO BE SIGNIFICANT AT P LESS THAN 0.02. "THE G-6-PD DEFICIENT BABIES ALREADY START OFF LIFE WITH A SIGNIFICANT HEMOLYISIS COMPARED WITH NORMAL G-6-PD BABIES. THEIR LIVERS CAN BE AFFECTED BY THE ALKALOIDS SO THAT CONJUGATION OF BILIRUBIN IS REDUCED RESULTING IN SEVERE JAUNDICE". THESE CASES WERE REPORTED FROM SINGAPORE. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN(PREGNANT) |
| Dose expression | DOSE |
| Extract | HOT H2O EXT |