Experiment 1099592
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Empty organism |
| Citation | MELTZER,HY: SIMONOVIC,M: GUDELSKY,GA:. (1983). EFFECT OF YOHIMBINE ON RAT PROLACTIN SECRETION.. 224(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | ADMINISTRATION OF THE TITLE COMPOUND PRODUCED MARKED,DOSE-DEPENDENT,AND SUSTAINED INCREASES IN PLASMA PROLACTIN LEVELS. HOWEVER, YOHIMBINE DID NOT BLOCK THE INHIBITORY EFFECT OF DOPAMINE ON PROLACTIN RELEASE FROM RAT PITUITARY GLAND IN VITRO, AND DID NOT DISPLACE(3H)-SPIPERONE FROM BOVINE PITUITARY MEMBRANES. FURTHER,THE TITLE COMPOUND HAD NO EFFECT ON THE CONCENTRATION OF DOPAMINE IN PITUITARY STALK PLASMA OF ANESTHETIZED RATS,SUGGESTING THAT THE STIMULATION OF PROLACTIN RELEASE BY YOHIMBINE IS NOT DUE TO ITS ANTIDOPAMINERGIC EFFECTS. |
| Dose amount | 5-25 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |