Experiment 1099709
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Senecio jacobaea (ASTERACEAE) |
| Citation | MIRANDA,CL: HENDERSON,MC: BUHLER,DR: SCHMITZ,JA:. (1982). COMPARATIVE EFFECTS OF ANTIOXIDANTS ON THE TOXICITY OF MIXED PYRROLIZIDINE ALKALOIDS FROM SENECIO JACOBAEA IN MICE.. 9() |
| Amount utilized | |
| Compound isolated | |
| Disease | 6 WEEK OLD MICE WERE FED AD LIBITUM A BASAL DIET WITH OR WITHOUT SEVERAL DIFFERENT ANTIOXIDANTS TO DETERMINE IF SUBSEQUENT CHALLENGE WITH PYRROLIZIDINE ALKALOIDS OF SENECIO JACOBAEA COULD RESULT IN REDUCED TOXICITY. AFTER FEEDING FOR 10 DAYS, A SINGLE INJECTION OF THE SENECIO EXTRACT WAS MADE. AFTER 24 HOURS, THE MICE WERE KILLED AND LIVERS WERE REMOVED FOR HISTOPATHOLOGICAL EXAMINATION. ANIMALS RECEIVING THE BASAL RATION AND THE SINGLE INJECTION OF PYRROLIZIDINE ALKALOIDS FROM SENECIO JACOBAEA HAD 100% MORTALITY WITH 24 HOURS. ADDITION OF 0.75% BUTYLATED HYDROXYANISOLE TO THE DIET PREVENTED DEATHS FOLLOWING SENECIO JACOBAEA INJECTION. DIETARY ETHOXYQUIN SIGNIFICANTLY REDUCED TOXICITY BUT DIETARY CYSTEINE DID NOT. |
| Dose amount | 280.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | ALKALOID FRACT |
| Gender | FEMALE |