Experiment 1099717
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IN RATION |
| Organism | Senecio jacobaea (ASTERACEAE) |
| Citation | SWICK,RA: CHEEKE,PR: GEOGER,DE: BUHLER,DR:. (1982). EFFECTS OF DIETARY SENECIO JACOBAEA AND INJECTED SENECIO ALKALOIDS AND MONOCROTALINE ON GUINEA PIGS.. 55() |
| Amount utilized | |
| Compound isolated | |
| Disease | DAILY FEEDING FOR 365 DAYS. THE CHRONIC LETHAL ORAL DOSE (LD100 WAS 1,264 GM/KG INITIAL WEIGHT OR 526% OF INITIAL BODY WEIGHT WITH AN AVERAGE SURVIVAL TIME OF 279 DAYS. THE ADDITION OF 1% CYSTEINE TO THE DIET WAS SLIGHTLY, BUT NOT SIGNIFICANTLY, PROTECTIVE AGAINST SENECIO JACOBAEA TOXICITY AS DETERMINED BY THE SURVIVAL TIME. HISTOPATHOLGICAL EXAMINATION OF THE LIVERS OF GUINEA PIGS RECEIVING THE TITLE PLANT REVEALED EXTENSIVE MEGALOCYTOSIS AND SEVERE CYTOPLASMIC VACUOLIZATION WITH BILIARY HYPERPLASIA AND FIBROSIS OCCURRING PRIMARILY IN THE PERIPORTAL AREAS. THE CENTRILOBULAR AND MIDZONAL AREAS APPEARED TO BE SOMEWHAT SPARED WITH THE WORST LESIONS OCCURRING IN THE PORTAL AREAS. |
| Dose amount | 10.0 % OF DIET |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | GUINEA PIG |
| Dose expression | CONC USED |
| Extract | PLANT |
| Gender | GIVEN TO BOTH SEXES |