Experiment 1100142
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | WALKER,BK: RAICH,PC: FONTANA,J: SUBRAMANIAN,VP: ROGERS II,JS: DENNING,B:. (1982). PHASE II STUDY OF VINDESINE IN PATIENTS WITH ADVANCED BREAST CANCER.. 66() |
| Amount utilized | |
| Compound isolated | |
| Disease | A PHASE II STUDY IN 20 PATIENTS WITH ADVANCED REFRACTORY BREAST CANCER. THE DRUG WAS ADMINISTRED BY I.V. BOLUS EVERY WEEK FOR SIX CONSECUTIVE WEEKS AND RESPONDING PATIENTS WERE MAINTAINED ON A DOSE OF 4 MG/SQ M EVERY TWO WEEKS. NINETEEN PATIENTS WERE EVALUABLE FOR DISEASE RESPONSE. PARTIAL REMISSIONS WERE OBTAINED IN FIVE PATIENTS. LEUKOPENIA WAS THE MAJOR DOSE-LIMITING TOXIC REACTION, BUT MOST PATIENTS WERE ABLE TO TOLERATE THIS SCHEDULE WITHOUT DIFFICULTY. NEUROTOXICITY WAS MILD AND DID NOT REQUIRE DOSE REDUCTION. |
| Dose amount | 3.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | FEMALE |