Experiment 1100143
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | FIORENTINO,MV: SALVAGNO,L: SILENI,VC: PACCAGNELLA,A: FERRAZZI,E: ZAGONEL,V: FOSSER,V:. (1982). VINDESINE OVERDOSE.. 66() |
| Amount utilized | |
| Compound isolated | |
| Disease | A REPORT OF A CASE OF OVERDOSE WITH VINDESINE. A 67 YEAR OLD MALE WITH LUNG CANCER WAS TREATED WITH A COMBINATION OF CISPLATIN AND VINDESINE. THE PATIENT HAD HAD PRIOR CHEMOTHERAPY. BOTH HEMATOLOGIC AND NEUROLOGIC TOXICITY HAD BEEN LOW, AND A GOOD PARTIAL REMISSION WAS SHOWN RADIOLOGICALLY. INADVERTENTLY, DOSE 13 OF VINDESINE WAS 45 MG INSTEAD OF 4.5 MG AS INTENDED. THE PATIENT EXPERIENCE GENERAL MUSCLE PAIN AND TINNITUS, CAUSING ABSOLUTE SLEEPLESSNESS FOR TWO NIGHTS. SPHINCTERIC INCONTINENCE WITH DIARRHEA LASTED 48 HRS,COMPLETE INABILITY TO SWALLOW BECAUSE OF A BURNING SENSATION IN THE MOUTH. THIS LASTED FOR FOUR DAYS AND HICCUPS RESISTANT TO MEDICATION LASTED 16 DAYS. THE TREATMENT OF THE PATIENT IS DESCRIBED. THE EFFECTS OF OVERDOSE WERE REVERSIBLE. |
| Dose amount | 45.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | MALE |