Experiment 1100144
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | CHAUVERGNE,J: DURAND,M: BRUNET,R: BUI,BN: HOERNI,B: MAURIAC,L:. (1981). CHEMOTHERAPY ASSOCIATING MITOMYCIN C, THIOTEPA AND VINDESINE IN ADVANCED BREAST CANCERS. STUDY OF 100 CASES.. 68() |
| Amount utilized | |
| Compound isolated | |
| Disease | ONE HUNDRED PATIENTS SUFFERING FROM ADVANCED BREAST CANCER AND RESISTING TO ONE (915) OR SEVERAL (85) DRUGS PREVIOUSLY ADMINISTERED WERE TREATED WITH A COMBINATION OF VINDESINE, MITOMYCIN C AND THIOTEPA, GIVEN EVERY THREE WEEKS. TOXIC EFFECTS WERE FREQUENTLY OBSERVED AND IT WAS NECESSARY TO STOP TREATMENT IN 25% OF CASES. AN OVERALL OBJECTIVE RESPONSE WAS OBTAINED IN 41 CASES AND A REGRESSION IN MORE THAN 50 PER CENT OF THE LESIONS WITH A MEDIAN DURATION OF 7.5 MONTHS WAS OBSERVED IN 15 CASES. THE MOST STRIKING EFFECTS WERE NOTED IN LYMPH NODES AND SKIN INVOLVEMENT WITH AN APPRECIABLE EFFECT ON THE FUNCTIONAL AND PAINFUL SYNDROME IN 60% OFTHE CASES. |
| Dose amount | 4.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | FEMALE |