Experiment 1100146

Details

PropertyValue
Pharmacology
Administration routeGASTRIC INTUBATION
OrganismSenecio jacobaea (ASTERACEAE)
CitationJOHNSON,AE:. (1982). FAILURE OF MINERAL-VITAMIN SUPPLEMENTS TO PREVENT TANSY RAGWORT(SENECIO JACOBAEA) TOXICOSIS IN CATTLE.. 43()
Amount utilized
Compound isolated
DiseaseDALY DOSING FOR THREE DAYS FOLLOWED BY 17 DAYS OF DOSING AT 1.25 GM/KG. WITHIN 7 DAYS AFTER FULL DOSES OF TANSY RAGWORT WERE STARTED, FEED CONSUMPTION BEGAN TO DECREASE,AND BY DAY 11,SEVERAL CALVES WERE EATING ONLY HALF THEIR NORMAL AMOUNTS OF FEED. DRYNESS AND CRUSTINESS OF THE SKIN AROUND THE NOSE AND EYES BEGAN TO APPEAR AT THAT TIME. BY DAY 20, SEVERAL CALVES WERE SHOWING OBVIOUS SIGNS OF LETHARGY AND DEPRESSION. CALVES DIED ON DAYS 25,64,65,128,142 AND 8 DIED BEFORE DAY 41. CALVES THAT SURVIVED FOR LONGER TIMES ATE WELL AND REMAINED IN FAIR CONDITION UNTIL 2 TO 3 WEEKS BEFORE DEATH,WHEN THEIR FEED CONSUMPTION DECREASED SHARPLY. HISTOPATHOLOGICAL EXAMINATION OF POST-MORTEM HEPATIC TISSUE REVEALED TYPICAL HEPATIC SENECIOSIS IN ALL CALVES. A SEPERATE GROUP OF CALVES WERE FED TRANSY RAGWORT AND A MINERAL SUPPLEMENT. RESULTS WERE ABOUT THE SAME.
Dose amount0.62 GM
Number1
Qualitative resultACTIVE
AnimalCALF
Per unitKG
Dose expressionDOSE
ExtractPLANT