Experiment 1101779
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Melia azedarach (MELIACEAE) |
| Citation | OELRICHS,PB: HILL,MW: VALLELY,PJ: MAC LEOD, JK: MOLINSKI,TF:. (1983). TOXIC TETRANORTRITERPENES OF THE FRUITS OF MELIA AZEDARACH.. 22(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | DEATH 2-4 HOURS AFTER ADMINISTRATION. SYMPTOMS OF TOXICITY WERE MARKED BY SEVERE AND RAPID MUSCULAR CONTRACTIONS.ANIMALS COLLAPSED AND FREQUENTLY THE CONTRACTIONS WERE REPLACED BY SPASMODIC QUIVERING OF THE MUSCLES SIMILAR TO SHIVERING. THE HEART RATE WAS RAPID(180 BEATS/MIN) AND THE PUPILS WERE DILATED. BY 8 HOURS THE ANIMALS WERE COMATOSE WITH WEAK HEART BEAT(100 BEATS/MIN) AND SUBNORMAL BODY TEMPERATURES(LESS THAN 35C) AND THIS WAS FOLLOWED BY DEATH AT CA. 30 HOURS. |
| Dose amount | VAR |
| Number | 6 |
| Qualitative result | ACTIVE |
| Animal | PIG |
| Dose expression | DOSE |