Experiment 1115137
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | WAGSTAFF,J: ANDERSON,HA: SHIU,W: THATCHER,N:. (1983). PHASE II STUDY OF VINDESINE INFUSION IN VISCERAL METASTATIC MALIGNANT MELANOMA.. 67(9) |
| Amount utilized | |
| Compound isolated | |
| Disease | PATIENTS WITH STAGE II AND III PROGRESSIVE METASTATIC MALIGNANT MELANOMA WERE TREATED WITH DACARBAZINE AND ACTINOMYCIN D AS FIRST-LINE THERAPY.PATENTS WHO RELAPSED FOLLOWING THIS TREATMENT OR WHO FAILED TO RESPOND WERE ENTERED IN THIS STUDY. VINDESINE WAS ADMINISTERED AS A CONTINUOUS INFUSION IN NORMAL SALINE OVER 24 HOURS.A SECOND GROUP OF PATIENTS RECEIVED 6 MG/SQ M.INFUSIONS WERE REPEATED AT WEEKLY INTERVALS. IF THE WBC COUNT FELL TO LESS THAN 3 MILLION OR IF THE PLATELET COUNT FELL TO LESS THAN 100/ML THERAPY WAS DELAYED UNTIL RECOVERY. SIXTY-THREE COURSES WERE ADMINISTERED TO 15 PATENTS AT THE LOWER DOSE LEVEL AND AN ADDITIONAL THREE PATIENTS RECEIVED SEVEN COURSES AT THE HIGHER DOSE LEVEL. ALL OF THE PATIENTS HAD PROGRESSIVE VISCERAL METASTASES. TOXICITY WAS NOT A REASON FOR DISCONTINUING THERAPY IN ANY PATIENT. KARNOFSKY PERFORMANCE STATUS WAS NOT IMPROVED BY THE TREATMENT AND NO RESPONSES WERE SEEN IN ANY OF THE 15 PATIENTS. IN EVERY PATIENT THE REASON FOR DISCONTINUING THERAPY WAS PROGRESSIVE DISEASE. |
| Dose amount | 3.0 MG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |